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Document type:
journal article 
Author(s):
Trajkovic-Arsic, Marija; Kalideris, Evdokia; Siveke, Jens T 
Title:
The role of insulin and IGF system in pancreatic cancer. 
Abstract:
The importance of the IGF system in carcinogenesis has been established for many solid cancers. It is well known that individuals with higher circulating levels of the IGF1 ligand present an increased risk of cancer. However, therapies with monoclonal antibodies targeting the IGF1 receptor (IGF1R) have been largely unsuccessful. One of the potential reasons for this failure is the existence of the highly homologous insulin receptor (IR), which appears to be at least equally efficient as the IGF1...    »
 
Journal title abbreviation:
J Mol Endocrinol 
Year:
2013 
Journal volume:
50 
Journal issue:
Pages contribution:
R67-74 
Language:
eng 
Print-ISSN:
0952-5041 
TUM Institution:
II. Medizinische Klinik und Poliklinik