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Dokumenttyp:
journal article 
Autor(en):
Schlitzer, Andreas; McGovern, Naomi; Teo, Pearline; Zelante, Teresa; Atarashi, Koji; Low, Donovan; Ho, Adrian W S; See, Peter; Shin, Amanda; Wasan, Pavandip Singh; Hoeffel, Guillaume; Malleret, Benoit; Heiseke, Alexander; Chew, Samantha; Jardine, Laura; Purvis, Harriet A; Hilkens, Catharien M U; Tam, John; Poidinger, Michael; Stanley, E Richard; Krug, Anne B; Renia, Laurent; Sivasankar, Baalasubramanian; Ng, Lai Guan; Collin, Matthew; Ricciardi-Castagnoli, Paola; Honda, Kenya; Haniffa, Muzlifah;...    »
 
Titel:
IRF4 transcription factor-dependent CD11b+ dendritic cells in human and mouse control mucosal IL-17 cytokine responses. 
Abstract:
Mouse and human dendritic cells (DCs) are composed of functionally specialized subsets, but precise interspecies correlation is currently incomplete. Here, we showed that murine lung and gut lamina propria CD11b+ DC populations were comprised of two subsets: FLT3- and IRF4-dependent CD24(+)CD64(-) DCs and contaminating CSF-1R-dependent CD24(-)CD64(+) macrophages. Functionally, loss of CD24(+)CD11b(+) DCs abrogated CD4+ T cell-mediated interleukin-17 (IL-17) production in steady state and after A...    »
 
Zeitschriftentitel:
Immunity 
Jahr:
2013 
Band / Volume:
38 
Heft / Issue:
Seitenangaben Beitrag:
970-83 
Sprache:
eng 
Print-ISSN:
1074-7613 
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik