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Autor(en):
Sterz, K.; Scherer, G.; Krumsiek, J.; Theis, F. J.; Ecker, J. 
Titel:
Identification and quantification of 1-hydroxybutene-2-yl mercapturic acid in human urine by UPLC- HILIC-MS/MS as a novel biomarker for 1,3-butadiene exposure 
Abstract:
1,3-Butadiene (BD) is a Class 1 carcinogen present at workplaces, in polluted air, in automobile exhaust, and in tobacco smoke. 2-Hydroxybutene-1-yl mercapturic acid (2-MHBMA) is a urinary metabolite often measured as a biomarker for exposure to BD. Here, we show for the first time that an additional MHBMA isomer is present at significant amounts in human urine, 1-hydroxybutene-2-yl mercapturic acid (1-MHBMA). For its quantification, a highly sensitive UPLC-HILIC-MS/MS method was developed and v...    »
 
Zeitschriftentitel:
Chem. Res. Toxicol. 
Jahr:
2012 
Band / Volume:
25 
Heft / Issue:
Seitenangaben Beitrag:
1565-1567