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Author(s):
Rickert, D.; Fricker, N.; Lavrik, I. N.; Theis, F. J. 
Title:
Systematic complexity reduction of signaling models and application to a CD95 signaling model for apoptosis 
Pages contribution:
57-84 
Abstract:
A major problem when designing mathematical models of biochemical processes to analyze and explain experimental data is choosing the correct degree of model complexity. A common approach to solve this problem is top-down: Initially, complete models including all possible reactions are generated; they are then iteratively reduced to a more manageable size. The reactions to be simplified at each step are often chosen manually since exploration of the full search space seems unfeasible. While such...    »
 
Editor:
Lavrik, I. N. 
Publisher:
Springer 
Publisher address:
New York 
Year:
2013