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Autor(en):
Marr, C.; Strasser, M.; Schwarzfischer, M.; Schroeder, T.; Theis, F. J. 
Titel:
Multi-scale modeling of GMP differentiation based on single-cell genealogies 
Abstract:
Hematopoiesis is often pictured as a hierarchy of branching decisions, giving rise to all mature blood cell types from stepwise differentiation of a single cell, the hematopoietic stem cell. Various aspects of this process have been modeled using various experimental and theoretical techniques on different scales. Here we integrate the more common population-based approach with a single-cell resolved molecular differentiation model to study the possibility of inferring mechanistic knowledge of t...    »
 
Stichworte:
Approximate Bayesian Computing Branching Process Differentiation Hematopoiesis Stochastic Gene Expression Model 
Zeitschriftentitel:
FEBS J. 
Jahr:
2012 
Band / Volume:
279 
Heft / Issue:
18 
Seitenangaben Beitrag:
3488-3500