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Autor(en):
Hock, S.; Hasenauer, J.; Theis, F. J. 
Titel:
Modeling of 2D diffusion processes based on microscopy data: Parameter estimation and practical identifiability analysis 
Abstract:
Background: Diffusion is a key component of many biological processes such as chemotaxis, developmental differentiation and tissue morphogenesis. Since recently, the spatial gradients caused by diffusion can be assessed in-vitro and in-vivo using microscopy based imaging techniques. The resulting time-series of two dimensional, high-resolutions images in combination with mechanistic models enable the quantitative analysis of the underlying mechanisms. However, such a model-based analysis is stil...    »
 
Band / Teilband / Volume:
14 
Verlag / Institution:
Biomed Central 
Jahr:
2013