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Autor(en):
Chursov, A.; Kopetzky, S. J.; Leshchiner, I.; Kondofersky, I.; Theis, F. J.; Frishman, D.; Shneider, A. 
Titel:
Specific temperature-induced perturbations of secondary mRNA structures are associated with the cold-adapted temperature-sensitive phenotype of influenza A virus 
Abstract:
For decades, cold-adapted, temperature-sensitive (ca/ts) strains of influenza A virus have been used as live attenuated vaccines. Due to their great public health importance it is crucial to understand the molecular mechanism(s) of cold adaptation and temperature sensitivity that are currently unknown. For instance, secondary RNA structures play important roles in influenza biology. Thus, we hypothesized that a relatively minor change in temperature (32-39 degrees C) can lead to perturbations in...    »
 
Stichworte:
Influenza Rna Structure Temperature Vaccine 
Zeitschriftentitel:
RNA Biol. 
Jahr:
2012 
Band / Volume:
Heft / Issue:
10 
Seitenangaben Beitrag:
1266-1274