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Dokumenttyp:
journal article 
Autor(en):
Boettcher, S; Ziegler, P; Schmid, MA; Takizawa, H; van Rooijen, N; Kopf, M; Heikenwalder, M; Manz, MG 
Titel:
Cutting Edge: LPS-Induced Emergency Myelopoiesis Depends on TLR4-Expressing Nonhematopoietic Cells. 
Abstract:
Systemic bacterial infection is rapidly recognized as an emergency state leading to neutrophil release into the circulation and increased myeloid cell production within the bone marrow. However, the mechanisms of sensing infection and subsequent translation into emergency myelopoiesis have not been defined. In this study, we demonstrate in vivo in mice that, surprisingly, selective TLR4 expression within the hematopoietic compartment fails to induce LPS-driven emergency myelopoiesis. In contrast...    »
 
Zeitschriftentitel:
J Immunol 
Jahr:
2012 
Band / Volume:
188 
Heft / Issue:
12 
Seitenangaben Beitrag:
5824-8 
Sprache:
eng 
Print-ISSN:
0022-1767 
TUM Einrichtung:
r Virologie