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Document type:
journal article 
Author(s):
Nagaraja, GM; Kaur, P; Neumann, W; Asea, EE; Bausero, MA; Multhoff, G; Asea, A 
Title:
Silencing Hsp25/Hsp27 gene expression augments proteasome activity and increases CD8+ T-cell-mediated tumor killing and memory responses. 
Abstract:
Relatively high expression of Hsp27 in breast and prostate cancer is a predictor of poor clinical outcome. This study elucidates a hitherto unknown mechanism by which Hsp27 regulates proteasome function and modulates tumor-specific T-cell responses. Here, we showed that short-term silencing of Hsp25 or Hsp27 using siRNA or permanent silencing of Hsp25 using lentivirus RNA interference technology enhanced PA28? mRNA expression, PA28? protein expression, and proteasome activity; abrogated metasta...    »
 
Journal title abbreviation:
Cancer Prev Res (Phila Pa) 
Year:
2012 
Journal volume:
Journal issue:
Pages contribution:
122-37 
Language:
eng 
Print-ISSN:
1940-6207 
TUM Institution:
Klinik und Poliklinik für Strahlentherapie und Radiologische Onkologie