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Document type:
journal article 
Author(s):
Nicolaije, C; Diderich, KE; Botter, SM; Priemel, M; Waarsing, JH; Day, JS; Brandt, RM; Schilling, AF; Weinans, H; Van der Eerden, BC; van der Horst, GT; Hoeijmakers, JH; van Leeuwen, JP 
Title:
Age-related skeletal dynamics and decrease in bone strength in DNA repair deficient male trichothiodystrophy mice. 
Abstract:
Accumulation of DNA damage caused by oxidative stress is thought to be one of the main contributors of human tissue aging. Trichothiodystrophy (TTD) mice have a mutation in the Ercc2 DNA repair gene, resulting in accumulation of DNA damage and several features of segmental accelerated aging. We used male TTD mice to study the impact of DNA repair on bone metabolism with age. Analysis of bone parameters, measured by micro-computed tomography, displayed an earlier decrease in trabecular and cortic...    »
 
Journal title abbreviation:
PLoS ONE 
Year:
2012 
Journal volume:
Journal issue:
Pages contribution:
e35246 
Language:
eng 
TUM Institution:
Klinik und Poliklinik für Plastische Chirurgie und Handchirurgie