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Dokumenttyp:
journal article 
Autor(en):
Schierberl, K; Giordano, T; Satpute, S; Hao, J; Kaur, G; Hofmann, F; Moosmang, S; Striessnig, J; Rajadhyaksha, A 
Titel:
Ca(v)1.3 L-type Ca2+ channels mediate long-term adaptation in dopamine D2L-mediated GluA1 trafficking in the dorsal striatum following cocaine exposure 
Abstract:
AMPA receptor (AMPAR) plasticity at glutamatergic synapses in the mesostriatal dopaminergic pathway has been implicated in persistent cocaine-induced behavioral responses; however, the precise mechanism underlying these changes remains unknown. Utilizing cocaine psychomotor sensitization in mice we find that repeated cocaine results in a basal reduction of Ser 845 GluA1 and cell surface GluA1 levels in the dorsal striatum (dStr) following a protracted withdrawal period, an adaptation that is de...    »
 
Zeitschriftentitel:
Channels 
Jahr:
2012 
Band / Volume:
Heft / Issue:
Seitenangaben Beitrag:
11-17 
Sprache:
eng 
Print-ISSN:
0009-1510 
TUM Einrichtung:
r Pharmakologie und Toxikologie