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Dokumenttyp:
journal article 
Autor(en):
Herrmann, S; Hofmann, F; Stieber, J; Ludwig, A 
Titel:
HCN channels in the heart: lessons from mouse mutants. 
Abstract:
Hyperpolarization-activated cation channels generate the I(f) current in the heart. In the sino-atrial node (SAN), I(f) is thought to play an essential role in setting the heart rate and mediating its autonomic control. This review focuses on the role of I(f) in pacemaking and non-pacemaking cardiomyocytes and the resulting therapeutic implications. HCN4 represents the principal isoform underlying sino-atrial I(f) , but other isoforms may also be of importance. To examine the functional role of...    »
 
Zeitschriftentitel:
Br J Pharmacol 
Jahr:
2012 
Band / Volume:
166 
Heft / Issue:
Seitenangaben Beitrag:
501-9 
Sprache:
eng 
Print-ISSN:
0007-1188 
TUM Einrichtung:
r Pharmakologie und Toxikologie