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Document type:
journal article 
Author(s):
Xu, X; Keshwani, M; Meyer, K; Sarikas, A; Taylor, S; Pan, ZQ 
Title:
Identification of the degradation determinants of insulin receptor substrate 1 for signaling cullin-RING E3 ubiquitin ligase 7-mediated ubiquitination. 
Abstract:
Negative feedback regulation of insulin signaling involves ubiquitin-dependent degradation of insulin receptor substrate 1 (IRS1).Cullin-RING E3 ubiquitin ligase 7 (CRL7) mediates the ubiquitination of IRS1 in hyperphosphorylated form.Multisite IRS1 phosphorylation triggers interactions with CRL7 for ubiquitin modification.Insulin signaling is self-restrained when its downstream effector kinases are hyperactivated to trigger the negative feedback inhibition. Hyperactivation of mechanistic target...    »
 
Journal title abbreviation:
J Biol Chem 
Year:
2012 
Journal volume:
287 
Journal issue:
48 
Pages contribution:
40758-66 
Language:
eng 
Print-ISSN:
0021-9258 
TUM Institution:
Institut für Pharmakologie und Toxikologie