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Dokumenttyp:
journal article 
Autor(en):
Blaich, A; Pahlavan, S; Tian, Q; Oberhofer, M; Poomvanicha, M; Lenhardt, P; Domes, K; Wegener, JW; Moosmang, S; Ruppenthal, S; Scholz, A; Lipp, P; Hofmann, F 
Titel:
Mutation of the calmodulin binding motif IQ of the L-type Ca(v)1.2 Ca2+ channel to EQ induces dilated cardiomyopathy and death. 
Abstract:
Cardiac excitation-contraction coupling (EC coupling) links the electrical excitation of the cell membrane to the mechanical contractile machinery of the heart. Calcium channels are major players of EC coupling and are regulated by voltage and Ca(2+)/calmodulin (CaM). CaM binds to the IQ motif located in the C terminus of the Ca(v)1.2 channel and induces Ca(2+)-dependent inactivation (CDI) and facilitation (CDF). Mutation of Ile to Glu (Ile1624Glu) in the IQ motif abolished regulation of the cha...    »
 
Zeitschriftentitel:
J Biol Chem 
Jahr:
2012 
Band / Volume:
287 
Heft / Issue:
27 
Seitenangaben Beitrag:
22616-25 
Sprache:
eng 
Print-ISSN:
0021-9258 
TUM Einrichtung:
r Pharmakologie und Toxikologie