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Dokumenttyp:
journal article 
Autor(en):
Bonnas, C; Specht, K; Spleiss, O; Froehner, S; Dietmann, G; Krüger, JM; Arbogast, S; Feuerhake, F 
Titel:
Effects of cold ischemia and inflammatory tumor microenvironment on detection of PI3K/AKT and MAPK pathway activation patterns in clinical cancer samples. 
Abstract:
The accuracy of common markers for PI3K/AKT and MAPK pathway activation in preclinical and clinical cancer biomarker studies depends on phosphoepitope stability and changes of phosphorylation under ischemia. Herein, we define conditions under which phosphoepitope-specific duplex immunohistochemistry (IHC) on formalin-fixed, paraffin-embedded tumor tissues reflects pathway activation in situ as accurately as possible, and identify activation patterns linked to mutational status, pathway dependenc...    »
 
Zeitschriftentitel:
Int J Cancer 
Jahr:
2012 
Band / Volume:
131 
Heft / Issue:
Seitenangaben Beitrag:
1621-32 
Sprache:
eng 
Print-ISSN:
0020-7136 
TUM Einrichtung:
r Allgemeine Pathologie und pathologische Anatomie