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Document type:
journal article 
Author(s):
Manook, A; Yousefi, BH; Willuweit, A; Platzer, S; Reder, S; Voss, A; Huisman, M; Settles, M; Neff, F; Velden, J; Schoor, M; von der Kammer, H; Wester, HJ; Schwaiger, M; Henriksen, G; Drzezga, A 
Title:
Small-animal PET imaging of amyloid-beta plaques with [11C]PiB and its multi-modal validation in an APP/PS1 mouse model of Alzheimer's disease. 
Abstract:
In vivo imaging and quantification of amyloid-? plaque (A?) burden in small-animal models of Alzheimer's disease (AD) is a valuable tool for translational research such as developing specific imaging markers and monitoring new therapy approaches. Methodological constraints such as image resolution of positron emission tomography (PET) and lack of suitable AD models have limited the feasibility of PET in mice. In this study, we evaluated a feasible protocol for PET imaging of A? in mouse brain wi...    »
 
Journal title abbreviation:
PLoS ONE 
Year:
2012 
Journal volume:
Journal issue:
Pages contribution:
e31310 
Language:
eng 
TUM Institution:
Nuklearmedizinische Klinik und Poliklinik; r Radiologie