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Dokumenttyp:
journal article 
Autor(en):
Busche, MA; Chen, X; Henning, HA; Reichwald, J; Staufenbiel, M; Sakmann, B; Konnerth, A 
Titel:
Critical role of soluble amyloid-? for early hippocampal hyperactivity in a mouse model of Alzheimer's disease. 
Abstract:
Alzheimer's disease (AD) is characterized by a progressive dysfunction of central neurons. Recent experimental evidence indicates that in the cortex, in addition to the silencing of a fraction of neurons, other neurons are hyperactive in amyloid-? (A?) plaque-enriched regions. However, it has remained unknown what comes first, neuronal silencing or hyperactivity, and what mechanisms might underlie the primary neuronal dysfunction. Here we examine the activity patterns of hippocampal CA1 neurons...    »
 
Zeitschriftentitel:
Proc Natl Acad Sci U S A 
Jahr:
2012 
Band / Volume:
109 
Heft / Issue:
22 
Seitenangaben Beitrag:
8740-5 
Sprache:
eng 
Print-ISSN:
0027-8424 
TUM Einrichtung:
r Psychiatrie und Psychotherapie; r Neurowissenschaften