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- Document type:
- Journal Article; Meta-Analysis; Review; Article
- Author(s):
- Etgen, T; Sander, D; Bickel, H; Sander, K; Förstl, H
- Title:
- Vitamin D deficiency, cognitive impairment and dementia: a systematic review and meta-analysis.
- Abstract:
- Recent preventive strategies for patients with cognitive impairment include the identification of modifiable somatic risk factors like vitamin D deficiency.A systematic literature research and meta-analysis were conducted to assess the association of cognitive impairment and vitamin D deficiency.Data from cross-sectional and longitudinal studies suggest an association between cognitive impairment and vitamin D deficiency. Meta-analysis of 5 cross-sectional and 2 longitudinal studies comprising 7,688 participants showed an increased risk of cognitive impairment in those with low vitamin D compared with normal vitamin D (OR 2.39, 95% CI 1.91-3.00; p < 0.0001).Methodological limitations of these studies comprise heterogeneity of study populations, different forms of cognitive assessment, the problem of reverse causality, different definitions of vitamin D deficiency and inconsistent control for confounders. As the value of vitamin D substitution in cognitive impairment remains doubtful, a long-time major placebo-controlled randomized trial of vitamin D supplementation in participants with mild cognitive impairment (MCI) should be started.
- Journal title abbreviation:
- Dement Geriatr Cogn Disord
- Year:
- 2012
- Journal volume:
- 33
- Journal issue:
- 5
- Pages contribution:
- 297-305
- Language:
- eng
- Fulltext / DOI:
- doi:10.1159/000339702
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/22759681
- Print-ISSN:
- 1420-8008
- TUM Institution:
- Klinik und Poliklinik für Psychiatrie und Psychotherapie; Neurologische Klinik und Poliklinik
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