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Dokumenttyp:
journal article 
Autor(en):
Etgen, T; Sander, D; Bickel, H; Sander, K; Förstl, H 
Titel:
Vitamin D deficiency, cognitive impairment and dementia: a systematic review and meta-analysis. 
Abstract:
Recent preventive strategies for patients with cognitive impairment include the identification of modifiable somatic risk factors like vitamin D deficiency.A systematic literature research and meta-analysis were conducted to assess the association of cognitive impairment and vitamin D deficiency.Data from cross-sectional and longitudinal studies suggest an association between cognitive impairment and vitamin D deficiency. Meta-analysis of 5 cross-sectional and 2 longitudinal studies comprising 7,688 participants showed an increased risk of cognitive impairment in those with low vitamin D compared with normal vitamin D (OR 2.39, 95% CI 1.91-3.00; p< 0.0001).Methodological limitations of these studies comprise heterogeneity of study populations, different forms of cognitive assessment, the problem of reverse causality, different definitions of vitamin D deficiency and inconsistent control for confounders. As the value of vitamin D substitution in cognitive impairment remains doubtful, a long-time major placebo-controlled randomized trial of vitamin D supplementation in participants with mild cognitive impairment (MCI) should be started. 
Zeitschriftentitel:
Dement Geriatr Cogn Disord 
Jahr:
2012 
Band / Volume:
33 
Heft / Issue:
Seitenangaben Beitrag:
297-305 
Sprache:
eng 
Print-ISSN:
1420-8008 
TUM Einrichtung:
r Psychiatrie und Psychotherapie; Neurologische Klinik und Poliklinik