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Dokumenttyp:
journal article 
Autor(en):
Weber, F; Cepok, S; Wolf, C; Berthele, A; Uhr, M; Bettecken, T; Buck, D; Hartung, HP; Holsboer, F; Müller-Myhsok, B; Hemmer, B 
Titel:
Single-nucleotide polymorphisms in HLA- and non-HLA genes associated with the development of antibodies to interferon-? therapy in multiple sclerosis patients. 
Abstract:
Interferons-? (IFN-?) are the most widely used immunomodulatory drugs for treatment of multiple sclerosis (MS). The development of neutralizing antibodies (NABs) against IFN-? is one of the main reasons for treatment failure. While formulation of the drug has a proven impact on the development of NABs, the genetic predisposition to develop antibodies is poorly understood. We performed genome-wide single-nucleotide polymorphism (SNP) genotyping in 362 MS patients of whom 178 had developed and 184...    »
 
Zeitschriftentitel:
Pharmacogenomics J 
Jahr:
2012 
Band / Volume:
12 
Heft / Issue:
Seitenangaben Beitrag:
238-45 
Sprache:
eng 
Print-ISSN:
1470-269X 
TUM Einrichtung:
Neurologische Klinik und Poliklinik