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Document type:
journal article 
Author(s):
Yu, P; Lübben, W; Slomka, H; Gebler, J; Konert, M; Cai, C; Neubrandt, L; da Costa, OP; Paul, S; Dehnert, S; Döhne, K; Thanisch, M; Storsberg, S; Wiegand, L; Kaufmann, A; Nain, M; Quintanilla-Martinez, L; Bettio, S; Schnierle, B; Kolesnikova, L; Becker, S; Schnare, M; Bauer, S 
Title:
Nucleic acid-sensing Toll-like receptors are essential for the control of endogenous retrovirus viremia and ERV-induced tumors. 
Abstract:
The genome of vertebrates contains endogenous retroviruses (ERVs) that are largely nonfunctional relicts of ancestral germline infection by exogenous retroviruses. However, in some mouse strains ERVs are actively involved in disease. Here we report that nucleic acid-recognizing Toll-like receptors 3, 7, and 9 (TLR 3, TLR7, and TLR9) are essential for the control of ERVs. Loss of TLR7 function caused spontaneous retroviral viremia that coincided with the absence of ERV-specific antibodies. Import...    »
 
Journal title abbreviation:
Immunity 
Year:
2012 
Journal volume:
37 
Journal issue:
Pages contribution:
867-79 
Language:
eng 
Print-ISSN:
1074-7613 
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene