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Document type:
journal article 
Author(s):
Van Beek, M; Oravecz-Wilson, KI; Delekta, PC; Gu, S; Li, X; Jin, X; Apel, IJ; Konkle, KS; Feng, Y; Teitelbaum, DH; Ruland, J; McAllister-Lucas, LM; Lucas, PC 
Title:
Bcl10 links saturated fat overnutrition with hepatocellular NF-kB activation and insulin resistance. 
Abstract:
Excess serum free fatty acids (FFAs) are fundamental to the pathogenesis of insulin resistance. With high-fat feeding, FFAs activate NF-kB in target tissues, initiating negative crosstalk with insulin signaling. However, the mechanisms underlying FFA-dependent NF-kB activation remain unclear. Here, we demonstrate that the saturated FA, palmitate, requires Bcl10 for NF-kB activation in hepatocytes. Uptake of palmitate, metabolism to diacylglycerol, and subsequent activation of protein kinase C (P...    »
 
Journal title abbreviation:
Cell Rep 
Year:
2012 
Journal volume:
Journal issue:
Pages contribution:
444-52 
Language:
eng 
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie