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Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't 
Autor(en):
Brüstle, A; Brenner, D; Knobbe, CB; Lang, PA; Virtanen, C; Hershenfield, BM; Reardon, C; Lacher, SM; Ruland, J; Ohashi, PS; Mak, TW 
Titel:
The NF-?B regulator MALT1 determines the encephalitogenic potential of Th17 cells. 
Abstract:
Effector functions of inflammatory IL-17-producing Th (Th17) cells have been linked to autoimmune diseases such as experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis (MS). However, what determines Th17 cell encephalitogenicity is still unresolved. Here, we show that after EAE induction, mice deficient for the NF-?B regulator MALT1 (Malt1-/- mice) exhibit strong lymphocytic infiltration in the CNS, but do not develop any clinical signs of EAE. Loss of Malt1 inter...    »
 
Zeitschriftentitel:
J Clin Invest 
Jahr:
2012 
Band / Volume:
122 
Heft / Issue:
12 
Seitenangaben Beitrag:
4698-709 
Sprache:
eng 
Volltext / DOI:
Print-ISSN:
0021-9738 
TUM Einrichtung:
Institut für Klinische Chemie und Pathobiochemie