User: Guest  Login
Document type:
journal article 
Author(s):
Brüstle, A; Brenner, D; Knobbe, CB; Lang, PA; Virtanen, C; Hershenfield, BM; Reardon, C; Lacher, SM; Ruland, J; Ohashi, PS; Mak, TW 
Title:
The NF-?B regulator MALT1 determines the encephalitogenic potential of Th17 cells. 
Abstract:
Effector functions of inflammatory IL-17-producing Th (Th17) cells have been linked to autoimmune diseases such as experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis (MS). However, what determines Th17 cell encephalitogenicity is still unresolved. Here, we show that after EAE induction, mice deficient for the NF-?B regulator MALT1 (Malt1-/- mice) exhibit strong lymphocytic infiltration in the CNS, but do not develop any clinical signs of EAE. Loss of Malt1 inter...    »
 
Journal title abbreviation:
J Clin Invest 
Year:
2012 
Journal volume:
122 
Journal issue:
12 
Pages contribution:
4698-709 
Language:
eng 
Print-ISSN:
0021-9738 
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie