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Dokumenttyp:
journal article 
Autor(en):
Gross, O; Yazdi, AS; Thomas, CJ; Masin, M; Heinz, LX; Guarda, G; Quadroni, M; Drexler, SK; Tschopp, J 
Titel:
Inflammasome activators induce interleukin-1? secretion via distinct pathways with differential requirement for the protease function of caspase-1. 
Abstract:
Through their capacity to sense danger signals and to generate active interleukin-1? (IL-1?), inflammasomes occupy a central role in the inflammatory response. In contrast to IL-1?, little is known about how IL-1? is regulated. We found that all inflammasome activators also induced the secretion of IL-1?, leading to the cosecretion of both IL-1 cytokines. Depending on the type of inflammasome activator, release of IL-1? was inflammasome dependent or independent. Calcium influx induced by the ope...    »
 
Zeitschriftentitel:
Immunity 
Jahr:
2012 
Band / Volume:
36 
Heft / Issue:
Seitenangaben Beitrag:
388-400 
Sprache:
eng 
Print-ISSN:
1074-7613 
TUM Einrichtung:
r Klinische Chemie und Pathobiochemie