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Dokumenttyp:
journal article 
Autor(en):
Heinz, LX; Rebsamen, M; Rossi, DC; Staehli, F; Schroder, K; Quadroni, M; Gross, O; Schneider, P; Tschopp, J 
Titel:
The death domain-containing protein Unc5CL is a novel MyD88-independent activator of the pro-inflammatory IRAK signaling cascade. 
Abstract:
The family of death domain (DD)-containing proteins are involved in many cellular processes, including apoptosis, inflammation and development. One of these molecules, the adapter protein MyD88, is a key factor in innate and adaptive immunity that integrates signals from the Toll-like receptor/interleukin (IL)-1 receptor (TLR/IL-1R) superfamily by providing an activation platform for IL-1R-associated kinases (IRAKs). Here we show that the DD-containing protein Unc5CL (also known as ZUD) is invol...    »
 
Zeitschriftentitel:
Cell Death Differ 
Jahr:
2012 
Band / Volume:
19 
Heft / Issue:
Seitenangaben Beitrag:
722-31 
Sprache:
eng 
Print-ISSN:
1350-9047 
TUM Einrichtung:
r Klinische Chemie und Pathobiochemie