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Dokumenttyp:
journal article 
Autor(en):
Fiebiger, BM; Moosmann, A; Behrends, U; Mautner, J 
Titel:
Mature proteins derived from Epstein-Barr virus fail to feed into the MHC class I antigenic pool. 
Abstract:
The immediate presentation of peptide epitopes on MHC class I (MHC I) after antigen expression has led to the concept that MHC I ligands are mostly derived from defective ribosomal products (DRiPs), a subset of newly synthesized proteins that are rapidly degraded by the proteasome. Whether and to what extent mature proteins contribute to the antigenic pool, however, has remained elusive. Here, we developed a conditional antigen expression system that allows studying antigen presentation from mat...    »
 
Zeitschriftentitel:
Eur J Immunol 
Jahr:
2012 
Band / Volume:
42 
Heft / Issue:
12 
Seitenangaben Beitrag:
3167-73 
Sprache:
eng 
Print-ISSN:
0014-2980 
TUM Einrichtung:
Kinderklinik und Poliklinik