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Document type:
journal article 
Author(s):
Dann, A; Poeck, H; Croxford, AL; Gaupp, S; Kierdorf, K; Knust, M; Pfeifer, D; Maihoefer, C; Endres, S; Kalinke, U; Meuth, SG; Wiendl, H; Knobeloch, KP; Akira, S; Waisman, A; Hartmann, G; Prinz, M 
Title:
Cytosolic RIG-I-like helicases act as negative regulators of sterile inflammation in the CNS. 
Abstract:
The action of cytosolic RIG-I-like helicases (RLHs) in the CNS during autoimmunity is largely unknown. Using a mouse model of multiple sclerosis, we found that mice lacking the RLH adaptor IPS-1 developed exacerbated disease that was accompanied by markedly higher inflammation, increased axonal damage and elevated demyelination with increased encephalitogenic immune responses. Furthermore, activation of RLH ligands such as 5'-triphosphate RNA oligonucleotides decreased CNS inflammation and impro...    »
 
Journal title abbreviation:
Nat Neurosci 
Year:
2012 
Journal volume:
15 
Journal issue:
Pages contribution:
98-106 
Language:
eng 
Print-ISSN:
1097-6256 
TUM Institution:
III. Medizinische Klinik und Poliklinik