Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Labisso, WL; Wirth, M; Stojanovic, N; Stauber, RH; Schnieke, A; Schmid, RM; Krämer, OH; Saur, D; Schneider, G 
Titel:
MYC directs transcription of MCL1 and eIF4E genes to control sensitivity of gastric cancer cells toward HDAC inhibitors. 
Abstract:
Histone deacetylases (HDACs) control fundamental physiological processes such as proliferation and differentiation. HDAC inhibitors (HDACi) induce cell cycle arrest and apoptosis of tumor cells. Therefore, they represent promising cancer therapeutics that appear particularly useful in combination therapies. Although HDACi are tested in current clinical trials, the molecular mechanisms modulating the cellular responses toward HDACi are incompletely understood. To gain insight into pathways that l...    »
 
Zeitschriftentitel:
Cell Cycle 
Jahr:
2012 
Band / Volume:
11 
Heft / Issue:
Seitenangaben Beitrag:
1593-602 
Sprache:
eng 
Print-ISSN:
1538-4101 
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik