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Dokumenttyp:
journal article 
Autor(en):
Jaitner, J; Morath, T; Byrne, RA; Braun, S; Gebhard, D; Bernlochner, I; Schulz, S; Mehilli, J; Schömig, A; Koch, W; Kastrati, A; Sibbing, D 
Titel:
No association of ABCB1 C3435T genotype with clopidogrel response or risk of stent thrombosis in patients undergoing coronary stenting. 
Abstract:
The prodrug clopidogrel requires intestinal absorption by the efflux pump P-glycoprotein MDR1 (multidrug resistant-1), encoded by the ABCB1 gene. Prior studies suggested that a common and functional genetic variant (C3435T, rs1045642) within ABCB1 influences clopidogrel treatment efficacy; however, existing data are highly inconsistent, because other studies failed to replicate this postulated association. Thus, the aim of this study was to assess the association of ABCB1 C3435T genotypes with...    »
 
Zeitschriftentitel:
Circ Cardiovasc Interv 
Jahr:
2012 
Band / Volume:
Heft / Issue:
Seitenangaben Beitrag:
82-8, S1-2 
Sprache:
eng 
Print-ISSN:
1941-7640 
TUM Einrichtung:
I. Medizinische Klinik und Poliklinik; r Herz- und Kreislauferkrankungen; r Laboratoriumsmedizin