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Document type:
journal article 
Author(s):
Eyer, F; Steimer, W; Nitzsche, T; Jung, N; Neuberger, H; Müller, C; Schlapschy, M; Zilker, T; Skerra, A 
Title:
Intravenous application of an anticalin dramatically lowers plasma digoxin levels and reduces its toxic effects in rats. 
Abstract:
Lipocalins tailored with high affinity for prescribed ligands, so-called anticalins, constitute promising candidates as antidotes. Here, we present an animal study to investigate both pharmacokinetic and clinical effects of an anticalin specific for the digitalis compound digoxin. Intravenous digoxin (2.5-50 ?g/kg/min) was administered to rats until first changes in the ECG occurred (dose finding study) or a priori for 30 min (kinetic study). The anticalin DigA16(H86N), dubbed DigiCal, was admin...    »
 
Journal title abbreviation:
Toxicol Appl Pharmacol 
Year:
2012 
Journal volume:
263 
Journal issue:
Pages contribution:
352-9 
Language:
eng 
Print-ISSN:
0041-008X 
TUM Institution:
Toxikologische Abteilung; r Klinische Chemie und Pathobiochemie