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Dokumenttyp:
journal article 
Autor(en):
Eyer, F; Steimer, W; Nitzsche, T; Jung, N; Neuberger, H; Müller, C; Schlapschy, M; Zilker, T; Skerra, A 
Titel:
Intravenous application of an anticalin dramatically lowers plasma digoxin levels and reduces its toxic effects in rats. 
Abstract:
Lipocalins tailored with high affinity for prescribed ligands, so-called anticalins, constitute promising candidates as antidotes. Here, we present an animal study to investigate both pharmacokinetic and clinical effects of an anticalin specific for the digitalis compound digoxin. Intravenous digoxin (2.5-50 ?g/kg/min) was administered to rats until first changes in the ECG occurred (dose finding study) or a priori for 30 min (kinetic study). The anticalin DigA16(H86N), dubbed DigiCal, was admin...    »
 
Zeitschriftentitel:
Toxicol Appl Pharmacol 
Jahr:
2012 
Band / Volume:
263 
Heft / Issue:
Seitenangaben Beitrag:
352-9 
Sprache:
eng 
Print-ISSN:
0041-008X 
TUM Einrichtung:
Toxikologische Abteilung; r Klinische Chemie und Pathobiochemie