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Dokumenttyp:
journal article 
Autor(en):
Dick, MG; Versmold, B; Engel, C; Meindl, A; Arnold, N; Varon-Mateeva, R; Sutter, C; Niederacher, D; Deissler, H; Preisler-Adams, S; Kast, K; Schäfer, D; Gadzicki, D; Heinritz, W; Wappenschmidt, B; Schmutzler, RK 
Titel:
Association of death receptor 4 variant (683A> C) with ovarian cancer risk in BRCA1 mutation carriers. 
Abstract:
Dysregulation of apoptosis plays an important role in carcinogenesis. Therefore, apoptosis-associated genes like the death receptor 4 (DR4, TRAIL-R1) are interesting candidates for modifying the penetrance of breast and ovarian cancer in carriers of BRCA1 and BRCA2 mutations. The DR-4 haplotype 626C-683C [626C> G, Thr209Arg (rs4871857) and 683A> C, Glu228Ala (rs17088993)] has recently been linked to an increased risk of breast cancer. To evaluate whether DR4 626C> G or DR4 683A> C modifies the r...    »
 
Zeitschriftentitel:
Int J Cancer 
Jahr:
2012 
Band / Volume:
130 
Heft / Issue:
Seitenangaben Beitrag:
1314-8 
Sprache:
eng 
Print-ISSN:
0020-7136 
TUM Einrichtung:
Frauenklinik und Poliklinik