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Dokumenttyp:
journal article 
Autor(en):
Couch, FJ; Gaudet, MM; Antoniou, AC; Ramus, SJ; Kuchenbaecker, KB; Soucy, P; Beesley, J; Chen, X; Wang, X; Kirchhoff, T; McGuffog, L; Barrowdale, D; Lee, A; Healey, S; Sinilnikova, OM; Andrulis, IL; OCGN; Ozcelik, H; Mulligan, AM; Thomassen, M; Gerdes, AM; Jensen, UB; Skytte, AB; Kruse, TA; Caligo, MA; von Wachenfeldt, A; Barbany-Bustinza, G; Loman, N; Soller, M; Ehrencrona, H; Karlsson, P; SWE-BRCA; Nathanson, KL; Rebbeck, TR; Domchek, SM; Jakubowska, A; Lubinski, J; Jaworska, K; Durda, K; Zlow...    »
 
Titel:
Common variants at the 19p13.1 and ZNF365 loci are associated with ER subtypes of breast cancer and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers. 
Abstract:
Genome-wide association studies (GWAS) identified variants at 19p13.1 and ZNF365 (10q21.2) as risk factors for breast cancer among BRCA1 and BRCA2 mutation carriers, respectively. We explored associations with ovarian cancer and with breast cancer by tumor histopathology for these variants in mutation carriers from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA).Genotyping data for 12,599 BRCA1 and 7,132 BRCA2 mutation carriers from 40 studies were combined.We confirmed associati...    »
 
Zeitschriftentitel:
Cancer Epidemiol Biomarkers Prev 
Jahr:
2012 
Band / Volume:
21 
Heft / Issue:
Seitenangaben Beitrag:
645-57 
Sprache:
eng 
Print-ISSN:
1055-9965 
TUM Einrichtung:
Frauenklinik und Poliklinik