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- Dokumenttyp:
- Journal Article; Research Support, Non-U.S. Gov't; Article
- Autor(en):
- Garcia-Etienne, CA; Tomatis, M; Heil, J; Friedrichs, K; Kreienberg, R; Denk, A; Kiechle, M; Lorenz-Salehi, F; Kimmig, R; Emons, G; Danaei, M; Heyl, V; Heindrichs, U; Rageth, CJ; Janni, W; Marotti, L; del Turco, MR; Ponti, A
- Titel:
- Mastectomy trends for early-stage breast cancer: a report from the EUSOMA multi-institutional European database.
- Abstract:
- Recent single-institution reports have shown increased mastectomy rates during the last decade. Further studies aiming to determine if these reports could be reflecting a national trend in the United States of America (US) have shown conflicting results. We report these trends from a multi-institutional European database.Our source of data was the eusomaDB, a central data warehouse of prospectively collected information of the European Society of Breast Cancer Specialists (EUSOMA). We identified patients with newly diagnosed unilateral early-stage breast cancer (stages 0, I or II) to examine rates and trends in surgical treatment.A total of 15,369 early-stage breast cancer cases underwent surgery in 13 Breast Units from 2003 to 2010. Breast conservation was successful in 11,263 cases (73.3%). Adjusted trend by year showed a statistically significant decrease in mastectomy rates from 2005 to 2010 (p = 0.003) with a progressive reduction of 4.24% per year. A multivariate model showed a statistically significant association of the following factors with mastectomy: age < 40 or >= 70 years, pTis, pT1mi, positive axillary nodes, lobular histology, tumour grade II and III, negative progesterone receptors and multiple lesions.Our study demonstrates that a high proportion of patients with newly diagnosed unilateral early-stage breast cancer from the eusomaDB underwent breast-conserving surgery. It also shows a significant trend of decreasing mastectomy rates from 2005 to 2010. Moreover, our study suggests mastectomy rates in the population from the eusomaDB are lower than those reported in the US.
- Zeitschriftentitel:
- Eur J Cancer
- Jahr:
- 2012
- Band / Volume:
- 48
- Heft / Issue:
- 13
- Seitenangaben Beitrag:
- 1947-56
- Sprache:
- eng
- Volltext / DOI:
- doi:10.1016/j.ejca.2012.03.008
- PubMed:
- http://view.ncbi.nlm.nih.gov/pubmed/22483323
- Print-ISSN:
- 0959-8049
- TUM Einrichtung:
- Frauenklinik und Poliklinik
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