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Dokumenttyp:
journal article 
Autor(en):
Wulfkuhle, JD; Berg, D; Wolff, C; Langer, R; Tran, K; Illi, J; Espina, V; Pierobon, M; Deng, J; Demichele, A; Walch, A; Bronger, H; Becker, I; Waldhör, C; Höfler, H; Esserman, L; on behalf of the I-SPY 1 TRIAL Investigators; Liotta, LA; Becker, KF; Petricoin, EF 
Titel:
Molecular Analysis of HER2 Signaling in Human Breast Cancer by Functional Protein Pathway Activation Mapping. 
Abstract:
PURPOSE: Targeting of the HER2 protein in human breast cancer represents a major advance in oncology but relies on measurements of total HER2 protein and not HER2 signaling network activation. We used reverse-phase protein microarrays (RPMA) to measure total and phosphorylated HER2 in the context of HER family signaling to understand correlations between phosphorylated and total levels of HER2 and downstream signaling activity. EXPERIMENTAL DESIGN: Three independent study sets, comprising a tota...    »
 
Zeitschriftentitel:
Clin Cancer Res 
Jahr:
2012 
Band / Volume:
18 
Heft / Issue:
23 
Seitenangaben Beitrag:
6426-6435 
Sprache:
eng 
Print-ISSN:
1078-0432 
TUM Einrichtung:
r Allgemeine Pathologie und pathologische Anatomie; Frauenklinik und Poliklinik