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Dokumenttyp:
journal article 
Autor(en):
Reinheckel, T; Peters, C; Krüger, A; Turk, B; Vasiljeva, O 
Titel:
Differential Impact of Cysteine Cathepsins on Genetic Mouse Models of De novo Carcinogenesis: Cathepsin B as Emerging Therapeutic Target. 
Abstract:
Lysosomal cysteine cathepsins belong to a family of 11 human proteolytic enzymes. Some of them correlate with progression in a variety of cancers and therefore are considered as potential therapeutic targets. Until recently, the contribution of individual cathepsins to tumorigenesis and tumor progression remained unknown. By crossing various types of mouse cancer models with mice where specific cathepsins have been ablated, we contributed to this gap of knowledge and will summarize the results i...    »
 
Zeitschriftentitel:
Front Pharmacol 
Jahr:
2012 
Band / Volume:
Seitenangaben Beitrag:
133 
Sprache:
eng 
TUM Einrichtung:
r experimentelle Onkologie und Therapieforschung