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Document type:
journal article 
Author(s):
Reinheckel, T; Peters, C; Krüger, A; Turk, B; Vasiljeva, O 
Title:
Differential Impact of Cysteine Cathepsins on Genetic Mouse Models of De novo Carcinogenesis: Cathepsin B as Emerging Therapeutic Target. 
Abstract:
Lysosomal cysteine cathepsins belong to a family of 11 human proteolytic enzymes. Some of them correlate with progression in a variety of cancers and therefore are considered as potential therapeutic targets. Until recently, the contribution of individual cathepsins to tumorigenesis and tumor progression remained unknown. By crossing various types of mouse cancer models with mice where specific cathepsins have been ablated, we contributed to this gap of knowledge and will summarize the results i...    »
 
Journal title abbreviation:
Front Pharmacol 
Year:
2012 
Journal volume:
Pages contribution:
133 
Language:
eng 
TUM Institution:
Institut für experimentelle Onkologie und Therapieforschung