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Dokumenttyp:
journal article 
Autor(en):
Wang, L; Schumann, U; Liu, Y; Prokopchuk, O; Steinacker, JM 
Titel:
Heat shock protein 70 (Hsp70) inhibits oxidative phosphorylation and compensates ATP balance through enhanced glycolytic activity. 
Abstract:
To address possible effects of heat shock protein 70 (Hsp70) on energy metabolism, we established a cell line expressing different levels of Hsp70 and evaluated changes in glucose and lactate metabolites, as well as ATP levels accordingly. In addition, activities of enzymes involved in glycolysis [phosphofructokinase (PFK) and lactate dehydrogenase (LDH)], Krebs cycle [citric synthase (CS)], and oxidative phosphorylation {NADH dehydrogenase [complex I (CI)] and ubiquinol:cytochrome-c reductase [...    »
 
Zeitschriftentitel:
J Appl Physiol 
Jahr:
2012 
Band / Volume:
113 
Heft / Issue:
11 
Seitenangaben Beitrag:
1669-76 
Sprache:
eng 
Print-ISSN:
8750-7587 
TUM Einrichtung:
Chirurgiesche Klinik und Poliklinik