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Document type:
journal article 
Author(s):
Aghdassi, A; Sendler, M; Guenther, A; Mayerle, J; Behn, CO; Heidecke, CD; Friess, H; Büchler, M; Evert, M; Lerch, MM; Weiss, FU 
Title:
Recruitment of histone deacetylases HDAC1 and HDAC2 by the transcriptional repressor ZEB1 downregulates E-cadherin expression in pancreatic cancer. 
Abstract:
Pancreatic cancer is characterised by invasive tumour spread and early metastasis formation. During epithelial-mesenchymal transition, loss of the cell adhesion molecule E-cadherin is frequent and can be caused by genetic or epigenetic modifications, recruitment of transcriptional activators/repressors or post-translational modifications. A study was undertaken to investigate how E-cadherin expression in human pancreatic adenocarcinoma and pancreatic cancer cell lines is regulated.In 25 human pa...    »
 
Journal title abbreviation:
Gut 
Year:
2012 
Journal volume:
61 
Journal issue:
Pages contribution:
439-48 
Language:
eng 
Print-ISSN:
0017-5749 
TUM Institution:
Chirurgiesche Klinik und Poliklinik