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Dokumenttyp:
journal article 
Autor(en):
Hösel, M; Broxtermann, M; Janicki, H; Esser, K; Arzberger, S; Hartmann, P; Gillen, S; Kleeff, J; Stabenow, D; Odenthal, M; Knolle, P; Hallek, M; Protzer, U; Büning, H 
Titel:
Toll-like receptor 2-mediated innate immune response in human nonparenchymal liver cells toward adeno-associated viral vectors. 
Abstract:
Adeno-associated viral vectors (rAAV) are frequently used in gene therapy trials. Although rAAV vectors are of low immunogenicity, humoral as well as T cell responses may be induced. While the former limits vector reapplication, the expansion of cytotoxic T cells correlates with liver inflammation and loss of transduced hepatocytes. Because adaptive immune responses are a consequence of recognition by the innate immune system, we aimed to characterize cell autonomous immune responses elicited by...    »
 
Zeitschriftentitel:
Hepatology 
Jahr:
2012 
Band / Volume:
55 
Heft / Issue:
Seitenangaben Beitrag:
287-97 
Sprache:
eng 
Print-ISSN:
0270-9139 
TUM Einrichtung:
r Virologie; Chirurgiesche Klinik und Poliklinik