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Dokumenttyp:
journal article 
Autor(en):
Aslam, M; Ahmad, N; Srivastava, R; Hemmer, B 
Titel:
TNF-alpha induced NF?B signaling and p65 (RelA) overexpression repress Cldn5 promoter in mouse brain endothelial cells. 
Abstract:
Inflammatory cytokine TNF? enhances permeability of brain capillaries constituting blood brain barrier (BBB). In the monoculture endothelial models of BBB TNF? alters tight junction (TJ) structure and protein content. Claudin-5 (Cldn5) is a key TJ protein whose expression in the brain endothelial cells is critical to the function of BBB. TNF? reduces Cldn5 promoter activity and mRNA expression in mouse brain derived endothelial cells but the regulatory elements and signaling mechanism involved a...    »
 
Zeitschriftentitel:
Cytokine 
Jahr:
2012 
Band / Volume:
57 
Heft / Issue:
Seitenangaben Beitrag:
269-75 
Sprache:
eng 
Print-ISSN:
1043-4666 
TUM Einrichtung:
Neurologische Klinik und Poliklinik