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Document type:
journal article 
Author(s):
Mykhaylyk, O; Sobisch, T; Almstätter, I; Sanchez-Antequera, Y; Brandt, S; Anton, M; Döblinger, M; Eberbeck, D; Settles, M; Braren, R; Lerche, D; Plank, C 
Title:
Silica-iron oxide magnetic nanoparticles modified for gene delivery: a search for optimum and quantitative criteria. 
Abstract:
To optimize silica-iron oxide magnetic nanoparticles with surface phosphonate groups decorated with 25-kD branched polyethylenimine (PEI) for gene delivery.Surface composition, charge, colloidal stabilities, associations with adenovirus, magneto-tranduction efficiencies, cell internalizations, in vitro toxicities and MRI relaxivities were tested for the particles decorated with varying amounts of PEI.Moderate PEI-decoration of MNPs results in charge reversal and destabilization. Analysis of spac...    »
 
Journal title abbreviation:
Pharm Res 
Year:
2012 
Journal volume:
29 
Journal issue:
Pages contribution:
1344-65 
Language:
eng 
Print-ISSN:
0724-8741 
TUM Institution:
Institut für experimentelle Onkologie und Therapieforschung ; Institut für Radiologie