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Dokumenttyp:
journal article 
Autor(en):
Hoffmann, J; Junker, H; Schmieder, A; Venz, S; Brandt, R; Multhoff, G; Falk, W; Radons, J 
Titel:
EGCG downregulates IL-1RI expression and suppresses IL-1-induced tumorigenic factors in human pancreatic adenocarcinoma cells. 
Abstract:
Human pancreatic cancer is currently one of the fifth-leading causes of cancer-related mortality with a 5-year survival rate of less than 5%. Since pancreatic carcinoma is largely refractory to conventional therapies, there is a strong medical need for the development of novel and innovative therapeutic strategies. Increasing evidence suggests an association of carcinogenesis and chronic inflammation. Because IL-1 plays a crucial role in inflammation-associated carcinogenesis, we analyzed the bi...    »
 
Zeitschriftentitel:
Biochem Pharmacol 
Jahr:
2011 
Band / Volume:
82 
Heft / Issue:
Seitenangaben Beitrag:
1153-62 
Sprache:
eng 
Print-ISSN:
0006-2952 
TUM Einrichtung:
r Strahlentherapie und Radiologische Onkologie