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Document type:
journal article 
Author(s):
Abdallah, BM; Ditzel, N; Mahmood, A; Isa, A; Traustadottir, GA; Schilling, AF; Ruiz-Hidalgo, MJ; Laborda, J; Amling, M; Kassem, M 
Title:
DLK1 is a novel regulator of bone mass that mediates estrogen deficiency-induced bone loss in mice. 
Abstract:
Delta-like 1/fetal antigen 1 (DLK1/FA-1) is a transmembrane protein belonging to the Notch/Delta family that acts as a membrane-associated or a soluble protein to regulate regeneration of a number of adult tissues. Here we examined the role of DLK1/FA-1 in bone biology using osteoblast-specific Dlk1-overexpressing mice (Col1-Dlk1). Col1-Dlk1 mice displayed growth retardation and significantly reduced total body weight and bone mineral density (BMD). Micro-computed tomographis (µCT) scanning reve...    »
 
Journal title abbreviation:
J Bone Miner Res 
Year:
2011 
Journal volume:
26 
Journal issue:
Pages contribution:
1457-71 
Language:
eng 
Print-ISSN:
0884-0431 
TUM Institution:
Klinik und Poliklinik für Plastische Chirurgie und Handchirurgie