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Dokumenttyp:
journal article 
Autor(en):
Meyer zu Hörste, G; Mausberg, AK; Müller, JI; Lehmann, HC; Löber, S; Gmeiner, P; Hartung, HP; Stüve, O; Korth, C; Kieseier, BC 
Titel:
Quinpramine ameliorates rat experimental autoimmune neuritis and redistributes MHC class II molecules. 
Abstract:
Activation of inflammatory cells is central to the pathogenesis of autoimmune demyelinating diseases of the peripheral nervous system. The novel chimeric compound quinpramine--generated from imipramine and quinacrine--redistributes cholesterol rich membrane domains to intracellular compartments. We studied the immunological and clinical effects of quinpramine in myelin homogenate induced Lewis rat experimental autoimmune neuritis (EAN), a model system for acute human inflammatory neuropathies, s...    »
 
Zeitschriftentitel:
PLoS ONE 
Jahr:
2011 
Band / Volume:
Heft / Issue:
Seitenangaben Beitrag:
e21223 
Sprache:
eng 
TUM Einrichtung:
Neurologische Klinik und Poliklinik