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Dokumenttyp:
journal article 
Autor(en):
Lambracht-Washington, D; Qu, BX; Fu, M; Anderson, LD; Stüve, O; Eagar, TN; Rosenberg, RN 
Titel:
DNA immunization against amyloid beta 42 has high potential as safe therapy for Alzheimer's disease as it diminishes antigen-specific Th1 and Th17 cell proliferation. 
Abstract:
The pathogenesis of Alzheimer's disease (AD) has been strongly associated with the accumulation of amyloid beta (A?) peptides in brain, and immunotherapy targeting A? provides potential for AD prevention. A clinical trial in which AD patients were immunized with A?42 peptide was stopped when 6% of participants showed meningoencephalitis, apparently due to an inflammatory Th1 immune response. Previously, we and other have shown that A?42 DNA vaccination via gene gun generates a Th2 cellular immun...    »
 
Zeitschriftentitel:
Cell Mol Neurobiol 
Jahr:
2011 
Band / Volume:
31 
Heft / Issue:
Seitenangaben Beitrag:
867-74 
Sprache:
eng 
Print-ISSN:
0272-4340 
TUM Einrichtung:
Neurologische Klinik und Poliklinik