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- Document type:
- Clinical Trial; Journal Article; Multicenter Study
- Author(s):
- Schwarzer, A; Urruzuno, P; Iwa?czak, B; Martínez-Gómez, MZ; Kalach, N; Roma-Giannikou, E; Liptay, S; Bontem, P; Buderus, S; Wenzl, TG; Koletzko, S
- Title:
- New effective treatment regimen for children infected with a double-resistant Helicobacter pylori strain.
- Abstract:
- The increasing number of pediatric patients infected with multiresistant Helicobacter pylori strains calls for evaluation of treatment regimens. Second-line antibiotics such as tetracycline or quinolones are not licensed for children. Because in vivo resistance to metronidazole may be overcome in vivo by a high dose and prolonged intake, we evaluated the eradication rate and side effects of a high-dose triple therapy in pediatric patients with culture-proven double resistance.In this open multicentre trial, 62 children (<18 years, body weight >15 kg) infected with an H pylori strain resistant to metronidazole and clarithromycin were treated according to body weight classes with amoxicillin (~ 75 mg/kg/day), metronidazole (~ 25 mg/kg/day) and esomeprazole (~ 1.5 mg/kg/day) for 2 weeks. Adherence and adverse events were assessed by a 2-week diary and telephone interviews at days 7 and 14 of treatment. Primary outcome was a negative C-urea breath test after 6 weeks.Of 62 patients, 5 were lost to follow-up, 12 were nonadherent, and 45 treated per protocol. Eradication rates were 66% (41/62) [confidence interval 54-78] (intention to treat) and 73% (33/45) [confidence interval 60-86] (per protocol). Success of treatment was not related to dose per kilogram body weight. Mild to moderate adverse events were reported by 21 patients, including nausea (10.8%), diarrhoea (8.9%), vomiting (7.1%), abdominal pain (5.4%), and headache (3.6%), and led to discontinuation in 1 child.High-dose amoxicillin, metronidazole, and esomeprazole for 2 weeks is a good treatment option in children infected with a double resistant H pylori strain.
- Journal title abbreviation:
- J Pediatr Gastroenterol Nutr
- Year:
- 2011
- Journal volume:
- 52
- Journal issue:
- 4
- Pages contribution:
- 424-8
- Language:
- eng
- Fulltext / DOI:
- doi:10.1097/MPG.0b013e3181fc8c58
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/21407111
- Print-ISSN:
- 0277-2116
- TUM Institution:
- Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin
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