Benutzer: Gast  Login
journal article 
Schwarzer, A; Urruzuno, P; Iwa?czak, B; Martínez-Gómez, MZ; Kalach, N; Roma-Giannikou, E; Liptay, S; Bontem, P; Buderus, S; Wenzl, TG; Koletzko, S; ESPGHAN Working Group on Helicobacter pylori Infection 
New effective treatment regimen for children infected with a double-resistant Helicobacter pylori strain. 
The increasing number of pediatric patients infected with multiresistant Helicobacter pylori strains calls for evaluation of treatment regimens. Second-line antibiotics such as tetracycline or quinolones are not licensed for children. Because in vivo resistance to metronidazole may be overcome in vivo by a high dose and prolonged intake, we evaluated the eradication rate and side effects of a high-dose triple therapy in pediatric patients with culture-proven double resistance.In this open multicentre trial, 62 children (<18 years, body weight>15 kg) infected with an H pylori strain resistant to metronidazole and clarithromycin were treated according to body weight classes with amoxicillin (~ 75 mg/kg/day), metronidazole (~ 25 mg/kg/day) and esomeprazole (~ 1.5 mg/kg/day) for 2 weeks. Adherence and adverse events were assessed by a 2-week diary and telephone interviews at days 7 and 14 of treatment. Primary outcome was a negative C-urea breath test after 6 weeks.Of 62 patients, 5 were lost to follow-up, 12 were nonadherent, and 45 treated per protocol. Eradication rates were 66% (41/62) [confidence interval 54-78] (intention to treat) and 73% (33/45) [confidence interval 60-86] (per protocol). Success of treatment was not related to dose per kilogram body weight. Mild to moderate adverse events were reported by 21 patients, including nausea (10.8%), diarrhoea (8.9%), vomiting (7.1%), abdominal pain (5.4%), and headache (3.6%), and led to discontinuation in 1 child.High-dose amoxicillin, metronidazole, and esomeprazole for 2 weeks is a good treatment option in children infected with a double resistant H pylori strain. 
J Pediatr Gastroenterol Nutr 
Band / Volume:
Heft / Issue:
Seitenangaben Beitrag:
TUM Einrichtung:
Kinderklinik und Poliklinik