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Dokumenttyp:
journal article 
Autor(en):
Ehrhardt, H; Schrembs, D; Moritz, C; Wachter, F; Haldar, S; Graubner, U; Nathrath, M; Jeremias, I 
Titel:
Optimized anti-tumor effects of anthracyclines plus Vinca alkaloids using a novel, mechanism-based application schedule. 
Abstract:
Application of anthracyclines and Vinca alkaloids on the same day represents a hallmark of polychemotherapy protocols for hematopoietic malignancies. Here we show, for the first time, that both drugs might act most efficiently if they are applied on different days. Proof-of-concept studies in 18 cell lines revealed that anthracyclines inhibited cell death by Vinca alkaloids in 83% of cell lines. Importantly, in a preclinical mouse model, doxorubicin reduced the anti-tumor effect of vincristine....    »
 
Zeitschriftentitel:
Blood 
Jahr:
2011 
Band / Volume:
118 
Heft / Issue:
23 
Seitenangaben Beitrag:
6123-31 
Sprache:
eng 
Print-ISSN:
0006-4971 
TUM Einrichtung:
Kinderklinik und Poliklinik