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Dokumenttyp:
journal article 
Autor(en):
Maak, M; Nitsche, U; Keller, L; Wolf, P; Sarr, M; Thiebaud, M; Rosenberg, R; Langer, R; Kleeff, J; Friess, H; Johannes, L; Janssen, KP 
Titel:
Tumor-specific targeting of pancreatic cancer with shiga toxin B-subunit. 
Abstract:
Pancreatic carcinoma is one of the most aggressive tumor entities, and standard chemotherapy provides only modest benefit. Therefore, specific targeting of pancreatic cancer for early diagnosis and therapeutic intervention is of great interest. We have previously shown that the cellular receptor for Shiga toxin B (STxB), the glycosphingolipid globotriaosylceramide (Gb(3) or CD77) is strongly increased in colorectal adenocarcinoma and their metastases. Here, we report an upregulation of Gb(3) in...    »
 
Zeitschriftentitel:
Mol Cancer Ther 
Jahr:
2011 
Band / Volume:
10 
Heft / Issue:
10 
Seitenangaben Beitrag:
1918-28 
Sprache:
eng 
Print-ISSN:
1535-7163 
TUM Einrichtung:
Chirurgiesche Klinik und Poliklinik; r Medizinische Statistik und Epidemiologie; r Allgemeine Pathologie und pathologische Anatomie